PNH LIVE APK is a Communication App that has got very good rating points and reviews. It is available on this trusted website for Android and iOS users. Paroxysmal nocturnal hemoglobinuria is a rare disease that happens when your body produces defective red blood cells. This can cause fatigue, headaches, and breathing problems.
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Paroxysmal nocturnal hemoglobinuria is a rare blood disorder with a single symptom: dark-colored urine is noticed during late-night or early-morning trips to the bathroom. In people with PNH, abnormal stem cells grow very fast in the bone marrow and make lots of red blood cells that have a mutant gene called PIG-A.
These red blood cells are highly vulnerable to premature destruction by a part of your immune system called the complement system. This destruction causes an overflow of hemoglobin, or protein that carries oxygen throughout your body.
The overflow damages your kidneys and can cause sudden painful spasms in your esophagus, stomach, or muscles in your back.
Paroxysmal nocturnal hemoglobinuria (PNH) is a blood disorder that affects people of all ages. The disease causes a shortage of red blood cells and excess hemoglobin from those cells to be released into the fluid that makes up your blood, known as plasma.
This can cause symptoms like hematuria and abnormally dark urine in the morning. Those with PNH also have a higher risk of developing blood clots and kidney damage.
The disease is caused by a genetic mutation that leaves your red blood cells without the normal proteins that help protect them from your immune system. Fortunately, treatment has made PNH much more manageable.
A few treatments increase the production of blood cells in your bone marrow, such as erythropoietin (EPO), which boosts the growth of new red blood cells. These medications may help reduce some of your PNH-related symptoms but do not cure the condition.
PNH LIVE APK can be diagnosed based on a complete blood count, bone marrow aspirate and biopsy, cytogenetics, and other tests. The most common test is the flow cytometry of peripheral blood granulocytes.
It enables assessment of the percentage of red blood cells that lack glycosylphosphatidylinositol-anchored proteins (GPI-APs) and identifies discrete populations with different degrees of deficiency.
The proportion of GPI-AP-deficient erythrocytes in the blood is related to hemolysis and clinical manifestations.
Patients with a high percentage of type III cells have clinically apparent hemolysis, whereas patients with a low proportion of these cells may have only biochemical evidence of hemolysis.
Because the clone size of a patient’s PNH erythrocytes is closely linked to the risk of thromboembolic disease, long-term anticoagulation should be considered in any patient with a PNH clone greater than 50%.
In addition, long-term anticoagulation should be reassessed in any patient who undergoes spontaneous remission or in whom the PNH clone size falls below 50%.
Treatment for PNH LIVE APK includes a combination of medications and treatments that help lower your symptoms and decrease your risk of developing life-threatening complications. These include medications called monoclonal antibodies, anticoagulants (drugs that reduce the chance of blood clots forming), and stem cell transplants.
The most commonly used drug is eculizumab, a monoclonal antibody that stops your immune system from breaking down red blood cells. It is given by intravenous infusion every 14 days.
It has been shown to be very effective in reducing hemolysis and improving the quality of life for many patients with moderate to severe PNH.
Your doctor may also recommend a supplement of iron and folate to improve your red blood cell production. This is because your body needs folic acid, or vitamin B9, to make red blood cells and your body’s supply of this nutrient may be depleted when your body destroys more red blood cells than it produces.
Thrombosis is the leading cause of death in people with PNH, but it can be prevented with anticoagulants and other treatments. Your doctor can also help you choose the right treatment for your condition and explain your options.